ChemicalBook--->CAS DataBase List--->40546-35-8

40546-35-8

40546-35-8 Structure

40546-35-8 Structure
IdentificationBack Directory
[Name]

Propionimidic acid ethyl ester HYDROCHLORIDE
[CAS]

40546-35-8
[Synonyms]

ethyl propionimidate hydrochloride*
ethyl propanecarboximidate hydrochloride
Propionimidic acid ethyl ester HYDROCHLORIDE
[Molecular Formula]

C5H12ClNO
[MDL Number]

MFCD00040974
[MOL File]

40546-35-8.mol
[Molecular Weight]

137.608
Questions And Answer(Q&A)Back Directory
[Preparation]

To a 250-ml round-bottomed, three-necked flask equipped with mechan­ical stirrer, dropping funnel, and condenser with a top outlet tube extend­ing into a saturated barium hydroxide solution is added 7.3 gm (0.10 mole) of propionamide. The flask is placed in a water bath at 40-45°C while 10.9 gm (0.10 mole) of ethyl chloroformate is added rapidly from the dropping funnel. The reaction mixture is rapidly stirred and in 15 min the reaction commences with the evolution of C02 as evidenced by precipita­tion in the Ba(OH)2 solution. After the carbon dioxide ceases to be evolved the product is washed with anhydrous ether and dried in a vacuum desiccator over cone, sulfuric acid to afford 8.9 gm (65%), m.p. 92-93°C.
Preparation of Ethyl Propionimidate Hydrochloride-1
The reaction of ethyl chloroformate with N-methyl or N-ethyl alkyla-mides afforded the corresponding N-alkyl imidate hydrochloride, a class of compounds for which no other direct method of synthesis exists. The reaction fails with acetanilide, n-butylacetamide, N-methyl-acetamide, and N-methylcaprylamide. However, thiobenzamide and thio-acetanilide each react with ethyl chloroformate to give ethyl benzimidate hydrochloride and ethyl N-phenylacetaimidate hydrochloride, respectively.
Preparation of Ethyl Propionimidate Hydrochloride-2
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H302-H315-H335
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
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