| Identification | Back Directory | [Name]
N3-PEG6-tBu | [CAS]
406213-76-1 | [Synonyms]
N3-PEG6-tBu
406213-76-1
Azido-PEG6-COOtBu
Azido-PEG6-C2-Boc
N3-PEG6-CH2CH2COOtBu
Azido-PEG7-t-butly ester
Azido-PEG7-t-butyl ester
tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate
21-Azido-4,7,10,13,16,19-hexaoxaheneicosanoic acid 1,1-dimethylethyl ester
N3-PEG6-CH2CH2COOtBu | [Molecular Formula]
C19H37N3O8 | [MDL Number]
MFCD20926385 | [MOL File]
406213-76-1.mol | [Molecular Weight]
435.512 |
| Hazard Information | Back Directory | [Description]
Azido-PEG6-t-butyl ester is a PEG molecule consisting of an azide group and a t-butyl ester moiety. he azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG5 spacer increases solubility in aqueous media. | [Uses]
Azido-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-C2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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