| Identification | Back Directory | [Name]
palovarotene | [CAS]
410528-02-8 | [Synonyms]
R 667
Ro 3300074
palovarotene
Unii-28K6I5m16g
R 667;RO 3300074
Palovarotene(R 667)
R667;R 667;R667;RO-3300074;RO 3300074;RO3300074
4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid
(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid
Benzoic acid, 4-[(1E)-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C27H30N2O2 | [MDL Number]
MFCD10565968 | [MOL File]
410528-02-8.mol | [Molecular Weight]
414.54 |
| Chemical Properties | Back Directory | [Melting point ]
249-252°C | [Boiling point ]
592.3±50.0 °C(Predicted) | [density ]
1.11 | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
4.26±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist.1 It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM.2 Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1R206H).3 It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H fibrodysplasia ossificans progressiva (FOP) mouse model.4 Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.5 | [Uses]
Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. | [Definition]
ChEBI: Palovarotene is a stilbenoid. |
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