| Identification | Back Directory | [Name]
5’O-Tritylinosine | [CAS]
4152-77-6 | [Synonyms]
KIN-59
5'-O-Trt-rI
5'-O-Trt-rI
5’O-Tritylinosine
Inosine, 5'-O-(triphenylmethyl)-
5'-O-tritylinosine-2'-deoxyinosine | [Molecular Formula]
C29H26N4O5 | [MDL Number]
MFCD29049997 | [MOL File]
4152-77-6.mol | [Molecular Weight]
510.54 |
| Chemical Properties | Back Directory | [solubility ]
DMF: 5 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.3 mg/mL | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC50s = 44 and 67 μM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice. | [Uses]
5’-O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase. | [Uses]
5’O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Carbosynth
|
| Tel: |
+86 512 6260 5585 |
| Website: |
www.carbosynth.com |
|