| Identification | Back Directory | [Name]
D-galactosyl--1,1' N-octanoyl-D-erythro-sphingosine | [CAS]
41613-16-5 | [Synonyms]
Octanoyl-Galactosylceramide
N-octanoyl-B-D-galactosylceramide
C8 Galactosylceramide (d18:1/8:0)
D-galactosyl--1,1' N-octanoyl-D-erythro-sphingosine
Octanamide, N-[(1S,2R,3E)-1-[(β-D-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]- | [Molecular Formula]
C32H61NO8 | [MOL File]
41613-16-5.mol | [Molecular Weight]
587.83 |
| Hazard Information | Back Directory | [Description]
C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo. It also activates NF-κB production in C6 glioma cells when used at a concentration of 10 μM. [Matreya, LLC. Catalog No. 1334] | [Definition]
ChEBI: C8 beta-D-galactosyl N-acylsphingosine is a D-galactosyl-N-acylsphingosine in which the glycosidic bond has beta-configuration and the ceramide N-acyl group is specified as octanoyl. It is a N-acyl-beta-D-galactosylsphingosine and a C8 beta-D-glycosyl N-acylsphingosine. |
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