| Identification | Back Directory | [Name]
3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) | [CAS]
4322-58-1 | [Synonyms]
-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) | [Molecular Formula]
C25H15ClO6 | [MOL File]
4322-58-1.mol | [Molecular Weight]
446.84 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; Ki = 50 μM).1,2 It also inhibits urease (IC50 = 84.53 μM for the Jack bean enzyme).3 | [References]
1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities Bioorg. Med. Chem. 14(23),8066-8072(2006).
2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, and small molecule inhibitors - A STING in the tale of ENPP1 Molecules 24(22),E4192(2019).
3. Khan, K.M., Iqbal, S., Lodhi, M.A., et al. Biscoumarin: New class of urease inhibitors; economical synthesis and activity Bioorg. Med. Chem. 12(8),1963-1968(2004). |
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