| Identification | Back Directory | [Name]
6-Aminooxy-hexanoic acid | [CAS]
448954-98-1 | [Synonyms]
hydrobromide, 10 mg
hydrobromide, 100 mg
HBr.H2N-O-(CH2)5-COOH
6-Aminooxy-hexanoic acid
NH2-O-C5-COOH hydrobromide
6-Aminooxy-hexanoic acid, HBr
6-Aminooxy-hexanoic acid,hydrobromide
6-Aminooxy-hexamoic acid hydrobromide | [Molecular Formula]
C6H13NO3.BrH | [MDL Number]
MFCD09743539 | [MOL File]
448954-98-1.mol | [Molecular Weight]
228.09 |
| Hazard Information | Back Directory | [Biological Activity]
NH2-O-C5-COOH (hydrobromide) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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