| Identification | Back Directory | [Name]
Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]- | [CAS]
450338-32-6 | [Synonyms]
TH301
Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]- | [Molecular Formula]
C24H24ClN3O4S | [MOL File]
450338-32-6.mol | [Molecular Weight]
485.98 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Waxy solid | [color ]
orange | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2.? It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics. | [References]
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