| Identification | Back Directory | [Name]
fenalamide | [CAS]
4551-59-1 | [Synonyms]
Femamide
Fenamide
Sch-5706
SH-30858
Spasmamide
fenalamide
ethyl 2-(2-diethylaminoethylcarbamoyl)-2-phenylbutanoate
ethyl 2-(2-diethylaminoethylcarbamoyl)-2-phenyl-butanoate
2-(2-diethylaminoethylcarbamoyl)-2-phenyl-butyric acid ethyl ester | [EINECS(EC#)]
224-917-2 | [Molecular Formula]
C19H30N2O3 | [MOL File]
4551-59-1.mol | [Molecular Weight]
334.457 |
| Hazard Information | Back Directory | [Originator]
Fenalamide,ZYF Pharm Chemical | [Uses]
Relaxant (smooth muscle). | [Definition]
ChEBI: Fenalamide is a member of acetamides. | [Manufacturing Process]
To a solution of 25.5 g of phenylethylmalonic acid ethyl ester chloride in 100
ml of anhydrous benzene 5.3 g of anhydrous sodium carbonate are added
followed by 11.6 g of N,N-diethylethylenediamine in small portion. After the
spontaneous heat evolution has subsided the mixture is refluxed for 2 hours
until the evolution of carbon dioxide ceases. After cooling the mixture is allowed to stand for some hours, the precipitated sodium chloride is removed
by filtration. The filtrat is evaporated to dryness in vacuo and the residue
distilled at 182-188°C/3 mm Hg.
The phenylethylmalonic acid (diethyl amino) ethylamide ethyl ester (free
base) is converted in hydrochloride by bubbling hydrogen chloride into a
diethyl ether solution of the free base; melting point 71-74°C. | [Therapeutic Function]
Spasmolytic, Smooth muscle relaxant |
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