| Identification | Back Directory | [Name]
ISOCORYDINE HYDROCHLORIDE | [CAS]
475-67-2 | [Synonyms]
luteanin
LUTEANINE
artabotrin
Aids138466
Uzokoridin
Aids-138466
Isocorydine
d-isocorydine
l-(+)-isocorydine
S-ISOCORYDINE (+)
(+)-isocorynoline
(+)-ISOCORYDINE HCL
luteanine(aporphine)
ISOCORYDINE HCL, (+)-
LUTEANINE HYDROCHLORIDE
ISOCORYDINE HYDROCHLORIDE
D-ISOCORYDINE HYDROCHLORIDE
(+)-ISOCORYDINE HYDROCHLORIDE
(+)-Isocorynoline hydrochloride
Aporphin-11-ol, 1,2,10-trimethoxy-
11-HYDROXY-1,2,10-TRIMETHOXYAPORPHINE
1,2,10-trimethoxy-6a-alpha-aporphin-11-o
11-HYDROXY-1,2,10-TRIMETHOXYAPORPHINE HYDROCHLORIDE
4h-dibenzo(de,g)quinolin-11-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methy
1,2,10-Trimethoxy-6-methyl-5,6,6A,7-tetrahydro-4H-dibenzo[de,G]quinolin-11-ol
(6aS)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol
(6aS)-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-11-ol
4H-Dibenzo[de,g]quinolin-11-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (6aS)-
[6aS,(+)]-5,6,6a,7-Tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-11-ol | [Molecular Formula]
C20H23NO4 | [MDL Number]
MFCD00134198 | [MOL File]
475-67-2.mol | [Molecular Weight]
341.4 |
| Chemical Properties | Back Directory | [Melting point ]
216-220 °C(lit.)
| [alpha ]
D20 +195° (chloroform) | [Boiling point ]
477.03°C (rough estimate) | [density ]
1.2064 (rough estimate) | [refractive index ]
1.5614 (estimate) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [pka]
9.41±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.1,2,3,4,5 It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM.2 Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM.3 It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively).4,5 Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.5 | [Uses]
sedative, cholinergic | [Definition]
ChEBI: Isocorydine is an aporphine alkaloid. | [target]
Dopamine Receptor | P450 (e.g. CYP17) | [References]
See Isocorydine |
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