| Identification | Back Directory | [Name]
5'-DEOXYADENOSINE | [CAS]
4754-39-6 | [Synonyms]
5′-dAdo
5'-DEOXYADENOSINE
5’-deoxy-adenosin
Adenosine, 5'-deoxy-
2'-Deoxycytidine Monohydrate(2'-dC ? H?O)
6-Amino-9-(5-deoxy-β-D-ribofuranosyl)-9H-purine
9-(5-Deoxy-β-D-ribofuranosyl)-9H-purine-6-amine
(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-methyl-oxolane-3,4-diol
5'-Deoxyadenosine methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase substrate | [Molecular Formula]
C10H13N5O3 | [MDL Number]
MFCD00056003 | [MOL File]
4754-39-6.mol | [Molecular Weight]
251.24 |
| Questions And Answer | Back Directory | [Description]
5'-Deoxyadenosine is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long been of interest in understanding the mechanism of aging, neurodegenerative diseases, and carcinogenesis. |
| Chemical Properties | Back Directory | [Melting point ]
210-212 °C | [Boiling point ]
595.0±60.0 °C(Predicted) | [density ]
1.93±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 15 mg/ml | [form ]
A crystalline solid | [pka]
13.29±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
XGYIMTFOTBMPFP-KQYNXXCUSA-N |
| Hazard Information | Back Directory | [Uses]
5′-Deoxyadenosine has been used:
- as a standard in mass spectroscopy
- as an inhibitor for screening thymidine phosphorylase activity
- as a substrate in 5′-Deoxyadenosine deaminase (DadD) assay
| [Definition]
ChEBI: A 5'-deoxyribonucleoside compound having adenosine as the nucleobase. | [Biochem/physiol Actions]
5′-Deoxyadenosine is a substrate for the enzyme methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in microbes. 5′-Deoxyadenosine is a byproduct of cleavage of S-adenosylmethionine (SAM). High levels of 5′-Deoxyadenosine inhibits SAM dependent enzymes. It also inhibits biotin synthase (BioB) and lipoyl synthase (LipA) enzymes. |
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