| Identification | Back Directory | [Name]
SENECIPHYLLIN | [CAS]
480-81-9 | [Synonyms]
JACODINE
NSC 30622
Aids002697
Aids-002697
NCI-C-61165
α-Longilobin
Seneciphynine
SENECIPHYLLIN
seneciphylline
seneciophylline
SENECIPHYLLIN(SG)
ALPHA-LONGILOBINE
oxy-6-methyl-5-methylene(1,6)dioxacyclodode///
3,19-Didehydro-12-hydroxysenecionan-11,16-dione
13,19-didehydro-12-hydroxysenecionan-11,16-dione
16-dione,13,19-didehydro-12-hydroxy-senecionan-1
16-dione,13,19-didehydro-12-hydroxy-senecionin-1
Senecionan-11,16-dione, 13,19-didehydro-12-hydroxy-
(15cis)-12-Hydroxy-13,19-didehydrosenecionan-11,16-dione
pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydr
Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene(1,6)dioxacyclododecino(2,3,4-gh)- | [Molecular Formula]
C18H23NO5 | [MDL Number]
MFCD00221722 | [MOL File]
480-81-9.mol | [Molecular Weight]
333.38 |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
217°C | [alpha ]
D -128° (chloroform) | [Boiling point ]
470.34°C (rough estimate) | [density ]
1.2467 (rough estimate) | [refractive index ]
1.5740 (estimate) | [storage temp. ]
?20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml | [form ]
neat | [pka]
12.43±0.20(Predicted) | [color ]
White to off-white | [Stability:]
Stable, but reacts with oxygen in the air. Incompatible with alkali, oxidizing agents. Store under inert gas. | [LogP]
0.810 (est) | [CAS DataBase Reference]
480-81-9 | [IARC]
3 (Vol. 10, Sup 7) 1987 | [EPA Substance Registry System]
Seneciphylline (480-81-9) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [General Description]
White powder. | [Air & Water Reactions]
Reacts slowly with atmospheric oxygen. . Insoluble in water. | [Reactivity Profile]
SENECIPHYLLIN is readily hydrolyzed with alkali; SENECIPHYLLIN reacts readily with oxidizing agents . | [Fire Hazard]
Flash point data are not available for SENECIPHYLLIN, but SENECIPHYLLIN is probably combustible. | [Description]
Seneciphylline, a pyrrolizidine alkaloid, one of the main components of Chinese medicine herb Tusanqi, which is a reason of the hepatic sinusoidal obstruction syndrome (HSOS). In addition, experiments on rats have shown that seneciphylline had adverse effects on the development and organic morphodifferentiation of embryos, thus the pregnant people exposed to Hebra may get potential risk on the fetus. | [Uses]
Seneciphylline is a minor constituent of S. jacobaea, which has been used as a medicinal herb in Europe. It has the effect of coagulation and hemostasis.
Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells. | [Application]
Seneciphylline is a naturally occurring plant toxin, which is employed to defend the plant against herbivore and insect attacks.
Seneciphylline may be used as an analytical reference standard for the quantification of the analyte in feed samples and traditional Chinese herbal medicines using different chromatography techniques. | [Definition]
ChEBI:LSM-2853 is a citraconoyl group. | [Health Hazard]
Seneciphylline and aflatoxin B. may be of greater importance as a cause of human disease than the presently known outbreaks of poisoning would indicate.
SYMPTOMS: Symptoms associated with this compound include abdominal pain, nausea and diarrhea, emaciation, intestinal edema and congestion of the liver. ACUTE/CHRONIC HAZARDS: Very toxic. (NTP, 1992) |
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