| Identification | Back Directory | [Name]
A-SPINASTEROL | [CAS]
481-18-5 | [Synonyms]
α
-amine D2
BESSISTEROL
spinasterol
Hitdesterol
Benzyl-α
HITODESTEROL
A-SPINASTEROL
Α-SPINASTEROL
SPINASTEROL, A-
alpha-Spinastero
ALPHA-SPINASTEROL
alpha-spinasterin
DELTA7-STIGMASTEROL
A-SPINASTEROL USP/EP/BP
(24R)-5α-Stigmasta-7,22-dien-3β-ol
(22E)-5α-Stigmasta-7,22-dien-3β-ol
(3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Stigmasta-7,22-dien-3-ol, (3β,5α,22E)-
(e)-5-alpha-stigmasta-22-dien-3-beta-ol
(3-beta,5-alpha,22e)-stigmasta-22-dien-3-ol
5-alpha-Stigmasta-7,22-dien-3-beta-ol, (E)-
(3-beta,5-alpha,22e)-stigmasta-7,22-dien-3-ol
7,22,5ALPHA-CHOLESTADIEN-24BETA-ETHYL-3BETA-OL
(3S,5S,9R,10S,13R,14R,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C29H48O | [MDL Number]
MFCD00200554 | [MOL File]
481-18-5.mol | [Molecular Weight]
412.69 |
| Chemical Properties | Back Directory | [Melting point ]
168-169° | [alpha ]
D25 -3.6° (c = 2.8 in chloroform) | [Boiling point ]
500.0±44.0 °C(Predicted) | [density ]
0.98±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
15.10±0.70(Predicted) | [color ]
White to Off-White | [biological source]
Aster scaber | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
α-Spinasterol was identified as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. | [Definition]
ChEBI: Alpha-Spinasterol is a steroid. It derives from a hydride of a stigmastane. | [Biological Activity]
α-Spinasterol is a blood-brain barrier-permeable and orally active plant phytosterol with antioxidantanticonvulsant (0.1-1 mg/kg i.p. in mice)antidepressant (1-2 mg/kg i.p. in mice) and anti-inflammatory (0.001-1 mg/kgi.p. or 1-10 mg/kgi.g. in mice) propertiesas well as antinociceptive efficacy via dual actions against transient receptor potential vanilloid 1 (TrpV1; IC50/Emax = 1.4 μM/67% against 2 nM RTX for binding mouse spinal cord membranes; IC50/Emax = 40 μM/62% against 20 μM capsaicin-induced mouse spinal cord synaptosomes Ca2+ influx) and cyclooxygenases (IC50 = 16.17 μM/COX1 and 7.76μM/COX2). a-spinasterol can directly affect membrane structure and packing in a manner similar to cholesterolboth a-spinasterol and stitosterol are reported to lower plasma/liver cholesterol levels and increase fecal cholesterol excretion when supplemented in daily diet (1%) in mice in vivo.''α-Spinasterol is a constituent of argan oi | [target]
TRPV | HMG-CoA reductase | [storage]
4°C, protect from light |
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