| Identification | Back Directory | [Name]
1,5-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE | [CAS]
484-49-1 | [Synonyms]
Olivacin
OLIVACINE
1,5-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE
6H-Pyrido[4,3-B]carbazole, 1,5-dimethyl-
Inchi=1/C17H14N2/C1-10-12-7-8-18-11(2)14(12)9-15-13-5-3-4-6-16(13)19-17(10)15/H3-9,19H,1-2h | [Molecular Formula]
C17H14N2 | [MDL Number]
MFCD00189403 | [MOL File]
484-49-1.mol | [Molecular Weight]
246.31 |
| Hazard Information | Back Directory | [Description]
This alkaloid has recently been shown to exhibit a marked antineoplastic activity.
Administration of 25 or 50 mg/kg intraperitoneally on alternate days or daily until
death to mice which had been inoculated with a single intraperitoneal dose of
106 -102 LI2l0 leukemia cells increased the survival time by 89-229 per cent
compared with control animals.
Japanese workers have recently reported the synthesis of olivacine by heating
indole with 4(1-hydroxyethyl)-3-methoxymethyl-2-methylpyridine in 47 per
cent HBr. | [Definition]
ChEBI:Olivacine is a member of carbazoles. | [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 27, p. 1751, 1990 DOI: 10.1002/jhet.5570270645 | [References]
Regina et al., Cienc. Cult. (Sao Paulo), 26, 517 (1974)
Synthesis:
Kametani et al., J. Chern. Soc., Perkin I, 2102 (1975) |
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