| Identification | Back Directory | [Name]
ProTx II | [CAS]
484598-36-9 | [Synonyms]
PT-II
ProTx II
ProToxin-II
ProTx II USP/EP/BP | [Molecular Formula]
C168H250N46O41S8 | [MDL Number]
MFCD16876402 | [MOL File]
484598-36-9.mol | [Molecular Weight]
3826.59 |
| Questions And Answer | Back Directory | [Uses]
ProTx-II is a potent, selective Nav1.7 blocker. Voltage-gated sodium channels (Nav) are responsible for transducing extracellular signals into action potentials in excitable cells. The Nav1 family consists of nine sub-types for which selective tools are highly valued. Discovery of subtype-selective tools has been challenging due to conservation of putative binding sites. Nav1.7 is expressed in sensory neurons and is critical for pain processing. ProTx-II, isolated from the tarantula Thrixopelma pruriens, is a potent blocker of Nav1 channels. Although ProTx-II blocks several members of this channel family, it has >100-fold selectivity for Nav1.7. ProTx-II is active in an in vitro model of pain processing. ProTx-II binds to a previously unknown site on the channel, conferring selectivity and increasing its value as a research tool. It blocks Nav1.7 by decreasing conductance and shifting the activation potential in the positive direction, resulting in an overall decrease in excitability. |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Soluble to 0.10 mg/ml in 4:1 Acetonitrile : water | [form ]
Powder | [Water Solubility ]
Soluble to 1 mg/ml in water |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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