| Identification | Back Directory | [Name]
RIMEXOLONE (100 MG) | [CAS]
49697-38-3 | [Synonyms]
Vexol
Rimexel
Org-6216
Rimexolone
Rimexolone D5
Rimexolone D6
(11β,16α,17β)-
RIMEXOLONE (100 MG)
Rimexolone (1604600)
Benzoyl Peroxide Impurity 9
Methylprednisolone Impurity 31 (Rimexolone)
11β-Hydroxy-16α,17α-dimethyl-17β-propionylandrosta-1,4-dien-3-one
(17S)-11β-Hydroxy-16α,17α-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one
(11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one
(11β, 16α, 17β)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androstra-1,4-dien-3-one
Androsta-1,4-dien-3-one, 11-hydroxy-16,17-dimethyl-17-(1-oxopropyl)-, (11β,16α,17β)- | [Molecular Formula]
C24H34O3 | [MDL Number]
MFCD00866123 | [MOL File]
49697-38-3.mol | [Molecular Weight]
370.52 |
| Chemical Properties | Back Directory | [Melting point ]
258-268 ºC | [alpha ]
D +100° (c = 0.92 in pyridine) | [Boiling point ]
507.0±50.0 °C(Predicted) | [density ]
1.12 | [pka]
14.42±0.70(Predicted) | [InChIKey]
QTTRZHGPGKRAFB-OOKHYKNYSA-N |
| Hazard Information | Back Directory | [Description]
Rimexolone, an ophthalmic corticosteroid, was launched in 1995 in the U.S.A. for
the treatment of postoperative inflammation following ocular surgery and anterior
uveitis. Rimexolone has high corticoid receptor affinity and is a potent local
antiinflammatory agent with minimal systemic effects and virtually no atrophogenic
action in many animal models studied, unique among a wide range of topical steroids.
Rapid onset, long duration of action plus a superior safety profile are characteristics of
rimexolone. It was also approved in Europe for the treatment of rheumatoid arthritis and
is currently in clinical trials for tendinitis and osteoarthritis. | [Originator]
Akzo (Netherlands) | [Uses]
Anti-inflammatory (local). | [Definition]
ChEBI:Rimexolone is a 20-oxo steroid. | [Brand name]
Vexol (Alcon). | [General Description]
Rimexolone, 11β-hydroxy-16α,17α-dimethyl-17-(1-oxopropyl)androsta-1,4-diene-3-one,like medrysone and fluorometholone, lacks the C21 OHgroup. In addition, rimexolone has an additional methylgroup in the 17 -position, a site where an OH group is typicallyfound. Rimexolone is available as a suspension forophthalmic use. |
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| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|