| Identification | Back Directory | [Name]
DL-GOITRIN | [CAS]
500-12-9 | [Synonyms]
DL-GOITRIN
(S)-Goitrin
(-)-Goitrin
Zinc05226611
Zinc05226613
photocatalyst
(+/-)-GOITRIN
()-GOITRIN 98%
(±)-Goitrin,98%
(5S)-5-Vinyloxazolidine-2-thione
(S)-5-Ethenyl-2-oxazolidinethione
2-Oxazolidinethione, 5-ethenyl-, (5S)- | [Molecular Formula]
C5H7NOS | [MDL Number]
MFCD00015467 | [MOL File]
500-12-9.mol | [Molecular Weight]
129.18 |
| Chemical Properties | Back Directory | [Melting point ]
50° | [alpha ]
D31 -70.5° (c = 2 in methanol) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
10.5(at 25℃) | [color ]
white to beige | [optical activity]
[α]/D 85 to 67° (C=1.0g/100mL, CDCl3 ) |
| Hazard Information | Back Directory | [Uses]
DL-Goitrin is a sulfur-containing oxazolidine, a cyclic thiocarbamate, that reduces the production of thyroid hormones such as thyroxine. | [Definition]
ChEBI: (S)-goitrin is a 5-ethenyl-1,3-oxazolidine-2-thione that has S-configuration. It is a constituent of a traditional Chinese herbal medicine, Radix isatidis. It has a role as an antiviral agent, a plant metabolite and an antithyroid drug. It is an enantiomer of a (R)-goitrin. | [Biological Activity]
Goitrin is a sulfur containing alkaloid isolated from Isatis indigotica (Ban Lan Gen) and Brassica vegetables (yellow turnipbroccoli) th at exhibits antiviralanticancerand antithyroid activities. Epigoitrin and goitrin appear to show virucidal effect on influenza virus A (H1N1) in vitro and in ovo. |
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