| Identification | Back Directory | [Name]
PHA 408 | [CAS]
503555-55-3 | [Synonyms]
PHA 408
PHA-408 >=98% (HPLC)
8-(5-Chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide
8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide
1H-Benz[g]indazole-3-carboxamide, 8-[[[5-chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro- | [Molecular Formula]
C29H27ClFN7O2 | [MDL Number]
MFCD17166977 | [MOL File]
503555-55-3.mol | [Molecular Weight]
560.02 |
| Chemical Properties | Back Directory | [Boiling point ]
727.4±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 5mg/mL, clear (warmed) | [form ]
powder | [pka]
10.18±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
PHA-408 is a potentselective I kappa B-kinase 2 (IKK-2) inhibitor. PHA-408 is a tight bindingATP competitive IKK-2 inhibitor with greater than 350-fold selectivity for IKK-2 vs IKK-1 (IC50 values of 10-40 nM at IKK-2 vs 14 μM at IKK-1). PHA-408 was shown to suppress inflammatory cellular eventsand to reduce inflammation in animal models of arthritis. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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