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50586-80-6

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50586-80-6 Structure

50586-80-6 Structure
IdentificationBack Directory
[Name]

m-PEG3-Tos
[CAS]

50586-80-6
[Synonyms]

m-PEG3-Tos
m-PEG2-Tos
mPEG2-Tosylate
MPEG3-TOSYLATE
m-dPEG??-tosylate
MeO(CH2)2O(CH2)2OTs
Ethanol, 2-(2-methoxyethoxy)-, 4-methylbenzenesulfonate
Ethanol, 2-(2-methoxyethoxy)-, 1-(4-methylbenzenesulfonate)
[Molecular Formula]

C12H18O5S
[MDL Number]

MFCD13184964
[MOL File]

50586-80-6.mol
[Molecular Weight]

274.33
Chemical PropertiesBack Directory
[Boiling point ]

392.3±27.0 °C(Predicted)
[density ]

1.179±0.06 g/cm3(Predicted)
[form ]

Solid-Liquid Mixture
[color ]

Colorless to white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Description]

m-PEG3-Tos is a PEG linker containing a tosyl group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
[Biological Activity]

m-PEG2-Tos is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It can also be used as a PROTAC linker for PROTAC synthesis. .
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[target]

Non-cleavable

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PEGs

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