| Identification | Back Directory | [Name]
nafiverine | [CAS]
5061-22-3 | [Synonyms]
DA-914
nafiverine
Nafiverina
Nafiverinum
Naftimepezine
UNII-WLT400RC9Q
EINECS 225-766-5
Bis(α-methyl-1-naphthaleneacetic acid)2,2'-(1,4-piperazinediyl)bisethyl ester
1-Naphthaleneacetic acid, α-methyl-, 1,1'-(1,4-piperazinediyldi-2,1-ethanediyl) ester
2-[4-[2-(2-naphthalen-1-ylpropanoyloxy)ethyl]piperazin-1-yl]ethyl 2-naphthalen-1-ylpropanoate | [EINECS(EC#)]
225-766-5 | [Molecular Formula]
C34H38N2O4 | [MDL Number]
MFCD00865213 | [MOL File]
5061-22-3.mol | [Molecular Weight]
538.684 |
| Hazard Information | Back Directory | [Originator]
Naftidan,De Angeli,Italy,1969 | [Definition]
ChEBI: Nafiverine is a member of naphthalenes. | [Manufacturing Process]
15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of
thionyl chloride during 3 hours. The excess thionyl chloride was removed
under reduced pressure and the product was also isolated by distillation under
reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl
chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)-
piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1-
naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with
stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester
were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared
by dissolving the ester in absolute ethanol and treating the solution with
anhydrous gaseous hydrogen chloride. | [Therapeutic Function]
Spasmolytic |
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