| Identification | Back Directory | [Name]
19-O-Acetylchaetoglobosin A | [CAS]
50939-69-0 | [Synonyms]
Chaetoglobosin A Acetate
19-O-Acetylchaetoglobosin A
12H-Cyclotridec[d]oxireno[f]isoindole-8,11,12-trione, 7-(acetyloxy)-3,4,7,13,14,14a,15,15a,16a,16b-decahydro-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-, (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)- (9CI) | [Molecular Formula]
C34H38N2O6 | [MOL File]
50939-69-0.mol | [Molecular Weight]
570.68 |
| Hazard Information | Back Directory | [Biological Activity]
19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities.1,2 It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.2 19-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 | [References]
1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975)
2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)
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