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5094-14-4

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5094-14-4 Structure

5094-14-4 Structure
IdentificationBack Directory
[Name]

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
[CAS]

5094-14-4
[Synonyms]

U 21002
13,14-dihydro-15-keto PGE1
CDUVSQMTLOYKTR-ZHALLVOQSA-N
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
9,15-dioxo-11α-hydroxy-prostan-1-oic acid
9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID
Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-
15-Keto Prostaglandin E0 DISCONTINUED, OFFER K202056
[Molecular Formula]

C20H34O5
[MDL Number]

MFCD00135210
[MOL File]

5094-14-4.mol
[Molecular Weight]

354.49
Chemical PropertiesBack Directory
[Boiling point ]

537.2±35.0 °C(Predicted)
[density ]

1.072±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer, Under inert atmosphere
[solubility ]

DMSO (Slightly), Methanol (Slightly), THF (Slightly)
[form ]

Oil
[pka]

4.77±0.10(Predicted)
[color ]

Dark Yellow
Hazard InformationBack Directory
[Description]

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM.
[Uses]

15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.
[Definition]

ChEBI: 13,14-dihydro-15-oxoprostaglandin E1 is a prostaglandin E obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin E1. It has a role as a human xenobiotic metabolite. It is functionally related to a prostaglandin E1. It is a conjugate acid of a 13,14-dihydro-15-oxoprostaglandin E1(1-).
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