| Identification | Back Directory | [Name]
ANKAFLAVIN | [CAS]
50980-32-0 | [Synonyms]
ANKAFLAVIN
Anti-cancer Activity
2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-9a-methyl-3-(1-oxooctyl)-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)- | [Molecular Formula]
C23H30O5 | [MDL Number]
MFCD32200995 | [MOL File]
50980-32-0.mol | [Molecular Weight]
386.48 |
| Chemical Properties | Back Directory | [Boiling point ]
590.7±50.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
10.75±0.60(Predicted) | [color ]
Light yellow to yellow |
| Questions And Answer | Back Directory | [Description]
Ankaflavin (AK), isolated from Monascus-Fermented red rice, is a PPARγ agonist with anti-inlfammatory activity. Ankaflavin is an active compound having anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.
| [Anti-cancer Activity]
Ankaflavin was found to be toxic to human cancer cell lines Hep G2 and A549 with a similar IC50 value of 15 μg/mL, while it posed no significant toxicity to normal MRC-5 and WI-38 cells at the same concentration.Ankaflavin exhibits selective cytotoxic effect and induces cell death on cancer cells.
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