| Identification | Back Directory | [Name]
4-isobutyloxazolidine-2,5-dione | [CAS]
51248-35-2 | [Synonyms]
ILE-NCA
H-DL-Leu-NCA
Einecs 257-083-3
Isobutyloxazolidine-2,5-dione
4-isobutyloxazolidine-2,5-dione
4-(2-Methylpropyl)-2,5-oxazolidinedione
4-(2-methylpropyl)oxazolidine-2,5-dione
2,5-Oxazolidinedione, 4-(2-methylpropyl)-
Isobutyloxazolidine-2,5-dione[H-DL-Leu-NCA
NCA of N-carboxyanhydride of raceMic DL-leucine | [EINECS(EC#)]
257-083-3 | [Molecular Formula]
C7H11NO3 | [MDL Number]
MFCD02684167 | [MOL File]
51248-35-2.mol | [Molecular Weight]
157.17 |
| Chemical Properties | Back Directory | [Melting point ]
47-48 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) | [density ]
1.124±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
9.38±0.40(Predicted) |
| Hazard Information | Back Directory | [Preparation]
A solution of phosgene(12.5% in toluene, 25 mL, 31.6 mmol) was added to a suspension of l-leucine (1.31 g, 10 mmol) in dioxane (30 mL) and ethyl acetate (25 mL) at 40 ℃ under a static atmosphere of nitrogen. After 4 h, the leucine had dissolved and then the excess phosgene was removed in a stream of nitrogen. The solvent was removed at 40 ℃ in vacuo and the residue was recrystallized from diethyl ether/light petroleum (bp 40–60 ℃) to yield colorless needles of 4-(2-methylpropyl)oxazolidine-2,5-dione (1.01 g, 69%). |
|
|