| Identification | Back Directory | [Name]
16-phenoxy tetranor Prostaglandin F2α methyl ester | [CAS]
51638-90-5 | [Synonyms]
16-phenoxy tetranor Prostaglandin F2α methyl ester
16-phenoxy tetranor Prostaglandin F2.alpha. methyl ester
16-phenoxy tetranor Prostaglandin F2α methyl ester Exclusive
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]cyclopentyl]-, methyl ester, (5Z)- | [Molecular Formula]
C23H32O6 | [MDL Number]
MFCD18427959 | [MOL File]
51638-90-5.mol | [Molecular Weight]
404.5 |
| Hazard Information | Back Directory | [Description]
Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid. | [Uses]
16-Phenoxy tetranor Prostaglandin F2α methyl ester is a metabolically stable form of Prostaglandin F2α that can binds to FP receptor. 16-Phenoxy tetranor Prostaglandin F2α methyl ester serves as prodrug that can be hydrolyzed to generate bioactive free acid[1]. | [storage]
Store at -20°C | [References]
[1] M Hayashi, Prostaglandin analogues possessing antinidatory effects. 2. Modification of the alpha chain. J Med Chem. 1980 May;23(5):525-35. DOI:10.1021/jm00179a011 |
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| Company Name: |
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www.bocsci.com |
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