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5184-64-5

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5184-64-5 Structure

5184-64-5 Structure
IdentificationBack Directory
[Name]

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
[CAS]

5184-64-5
[Synonyms]

ESI-05
NSC 116966
ESI-05 (ESI05)
ESI-05 >=98% (HPLC)
MESITYL P-TOLYL SULFONE
1,3,5-trimethyl-2-tosylbenzene
1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
[Molecular Formula]

C16H18O2S
[MDL Number]

MFCD00091573
[MOL File]

5184-64-5.mol
[Molecular Weight]

274.38
Chemical PropertiesBack Directory
[Melting point ]

119-120 °C
[Boiling point ]

426.7±45.0 °C(Predicted)
[density ]

1.129±0.06 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMSO: soluble
[form ]

powder
[color ]

white to beige
Hazard InformationBack Directory
[Uses]

ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.
[Biochem/physiol Actions]

ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.
[storage]

Store at RT
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