| Identification | Back Directory | [Name]
1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt | [CAS]
51876-97-2 | [Synonyms]
AY-22284A
Alrestatin sodium
sodium,2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetate
1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid sodium salt
1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt | [MOL File]
51876-97-2.mol |
| Hazard Information | Back Directory | [Originator]
Alrestatin,BIOMOL | [Uses]
Enzyme inhibitor (aldose reductase). | [Manufacturing Process]
1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid:
1,8-Naphthalic acid anhydride (110 g, 0.556 mole), glycine (48 g, 0.64 mole)
and dimethylformamide (750 ml) are heated and stirred at reflux for 2 hr. The
homogeneous dark solution is cooled to about 100°C and 750 ml of hot water
is added slowly to the stirred solution. The reaction mixture is cooled and
allowed to stand in a refrigerator for 16 hr. The precipitate is collected and
recrystallized from ethanol, using decolorizing charcoal, to give the title
compound, MP: 271°-272°C.
In practice it is usually used as sodium salt. | [Therapeutic Function]
Aldose reductase inhibitor |
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