| Identification | Back Directory | [Name]
14,15-EE-5(Z)-E | [CAS]
519038-92-7 | [Synonyms]
14,15-EE-5(Z)-E
KZTLOTWHEAHQAZ-VNULFWPXSA-N
14,15-Epoxy-5(Z)-Eicosaenoic Acid
13-[(2(R),3S)-3-pentyloxiranyl]-5(Z)-tridecenoic acid
5-Tridecenoic acid, 13-[(2R,3S)-3-pentyl-2-oxiranyl]-, (5Z)-rel- | [Molecular Formula]
C20H36O3 | [MDL Number]
MFCD12912220 | [MOL File]
519038-92-7.mol | [Molecular Weight]
324.5 |
| Chemical Properties | Back Directory | [Boiling point ]
452.4±18.0 °C(Predicted) | [density ]
0.957±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.5 mg/ml | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation. |
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