| Identification | Back Directory | [Name]
OTIORHLXOLCOAV-UHFFFAOYSA-N | [CAS]
51938-11-5 | [Synonyms]
OTIORHLXOLCOAV-UHFFFAOYSA-N
Chlorpromazine 7-Hydroxy Impurity
7-Hydroxy-chlorpromazine hydrochloride salt | [Molecular Formula]
C17H20Cl2N2OS | [MOL File]
51938-11-5.mol | [Molecular Weight]
371.325 |
| Hazard Information | Back Directory | [Uses]
7-Hydroxychlorpromazine is the 7-hydroxy analogue and a major metabolite of the atypical antipsychotic Chlorpromazine (C424750). | [Biological Activity]
7-hydroxy Chlorpromazine is an active metabolite of the typical antipsychotic chlorpromazine .1 In vivo, 7-hydroxy chlorpromazine (5 mg/kg) increases plasma prolactin levels in male rats. It also reverses D-amphetamine-induced depression of the dopaminergic neuronal firing rate in the rat substantia nigra in rats when administered at a dose of 1.6 mg/kg.2 | [References]
1.Meltzer, H.Y., Fang, V.S., Simonovich, M., et al.Effect of metabolites of chlorpromazine on plasma prolactin levels in male ratsEur. J. Pharmacol.41(4)431-436(1977)
2.Bunney, B.S., and Aghajanian, G.K.A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neuronsLife Sci.15(2)309-318(1974)
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Energy Chemical
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http://www.energy-chemical.com |
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ChemeGen 中国
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