ChemicalBook--->CAS DataBase List--->521-34-6

521-34-6

521-34-6 Structure

521-34-6 Structure
IdentificationBack Directory
[Name]

SCIADOPITYSIN
[CAS]

521-34-6
[Synonyms]

Nsc 45108
SCIADOPITYSIN
Einecs 208-311-5
SCIADOPITYSIN(SH)
4',4''',7-Trimethoxyamentoflavone
AMENTOFLAVONE-7,4',4'-TRIMETHYL ETHER
AMENTOFLAVONE-7,4',4''-TRIMETHYL ETHER
AMENTOFLAVONE-7,4',4'''-TRIMETHYL ETHER
Sciadopitysin, 95%, from Ginkgo biloba L.
AMENTOFLAVONE-7,4'',4''-TRIMETHYL ETHER WITH HPLC
5,5'',7''-Trihydroxy-4',4''',7-trimethoxy-3',8''-biflavone
5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one
5,7-Dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-methoxyphenyl)-4-benzopyrone
5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4-benzopyrone
2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5-hydroxy-7-methoxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one
2-(4-Methoxyphenyl)-8-[6-methoxy-3-(4-oxo-5-hydroxy-7-methoxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
5,7-Dihydroxy-8-[2-methoxy-5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-
[EINECS(EC#)]

208-311-5
[Molecular Formula]

C33H24O10
[MDL Number]

MFCD00017448
[MOL File]

521-34-6.mol
[Molecular Weight]

580.54
Chemical PropertiesBack Directory
[Melting point ]

296-298°C
[Boiling point ]

839.6±65.0 °C(Predicted)
[density ]

1.445±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

Soluble in ethanol and methan
[form ]

powder
[pka]

6.16±0.40(Predicted)
[color ]

Light yellow
[LogP]

5.500 (est)
[CAS DataBase Reference]

521-34-6
Safety DataBack Directory
[Safety Statements ]

24/25
[HS Code ]

29329990
Hazard InformationBack Directory
[Description]

Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in PC12 cells (EC50 = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel (Item No. 10461) in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.
[Definition]

ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.
[target]

ROS | MMP(e.g.TIMP) | NO | TNF-α | ATPase | cAMP | Beta Amyloid
[storage]

4°C, protect from light
Spectrum DetailBack Directory
[Spectrum Detail]

SCIADOPITYSIN(521-34-6)MS
SCIADOPITYSIN(521-34-6)IR1
SCIADOPITYSIN(521-34-6)IR2
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