| Identification | Back Directory | [Name]
KARANJIN | [CAS]
521-88-0 | [Synonyms]
Kranjin
KARANJIN
NSC 335755
karanjin from pongamia glabra oil
3-methoxy-2-phenylfuro[2,3-h]chromen-4-one
3-methoxy-2-phenyl-furo[2,3-h]chromen-4-one
3-Methoxy-2-phenyl-4H-furo[2,3-h]chromen-4-one
3-METHOXY-2-PHENYL-4H-FURO[2,3-H]-1-BENZOPYRAN-4-ONE
2-Phenyl-3-methoxy-4H-furo[2,3-h]-1-benzopyran-4-one
4H-Furo[2,3-h]-1-benzopyran-4-one, 3-methoxy-2-phenyl- | [EINECS(EC#)]
208-319-9 | [Molecular Formula]
C18H12O4 | [MDL Number]
MFCD00017406 | [MOL File]
521-88-0.mol | [Molecular Weight]
292.29 |
| Chemical Properties | Back Directory | [Melting point ]
156°C | [Boiling point ]
463.0±45.0 °C(Predicted) | [density ]
1.36 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Specific Gravity]
1.495 | [LogP]
3.290 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
Needle-shaped crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from water yellow skin, water Luo umbrella, water flow bean Pongamia pinnata, Mori fish vine Derris mollis. . | [Uses]
Aquaxanthin has an anti-tuberculosis effect. | [Definition]
ChEBI: Karanjin is an extended flavonoid. | [Biological Activity]
Karanjin is the main active furanoflavonol component in Fordia cauliflora. It induces GLUT4 translocation in skeletal muscle cells by increasing AMPK, and induces cancer cell death through cell cycle arrest and promotes apoptosis. | [in vivo]
Karanjin (50, 100 mg/kg, p.o., 6 h) reduces the blood glucose level of Streptozotocin (HY-13753)-induced diabetic rats[1].
Karanjin (20 mg/kg/d, p.o., 21 d) reduces joint injury and cartilage damage along with edema and erythema in the AIA model rats[1].
Karanjin (10, 20 mg/kg/d, p.o., 14 d) significantly decreases serum ACP, ALP and TNFα levels in the AIA model rats [1].
Karanjin (25 or 50 mg/kg/d, p.o. or i.g., 8 d) improved learning and memory in Diazepam-induced amnesia mice[1].
| Animal Model: | Streptozotocin-induced diabetic rats[1] | | Dosage: | 50, 100 mg/kg | | Administration: | Oral gavage (p.o.), wait for 6h | | Result: | Lowered the blood glucose level by 11.7% and 20.7% at 50 and 100 mg/kg gavage. |
| Animal Model: | Adjuvant induced arthritis model (AIA) Wistar strain male albino rats[1] | | Dosage: | 10, 20 mg/kg/d | | Administration: | Oral gavage (p.o.), 14 d for serum assay, 21 d for histological examination | | Result: | Reduced articular cartilage damage, cellular infiltration in the articular cartilage and spongy bone damage significantly. Decreased serum acid phosphatase, alkaline phosphatase levels and TNFα level markedly. |
| Animal Model: | Diazepam-induced male swiss albino mice [1] | | Dosage: | 25, 50 mg/kg/d | | Administration: | Oral gavage (p.o.) or Intraperitoneal injection (i.p.) for 8 d | | Result: | Decreased the transfer latency on all the observation days, significantly reversed diazepam-induced amnesia, indicating improved learning and memory in treated mice. |
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