| Identification | Back Directory | [Name]
Trimetrexate | [CAS]
52128-35-5 | [Synonyms]
CI-898
NSC249008
NSC-249008
Trimetrexate
CI-898; CI 898; CI898
CI-898;NSC-249008;CI898;NSC249008
5-Methyl-6-(3,4,5-trimethoxyanilinomethyl)quinazoline-2,4-diamine
5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine
5-Methyl-6-{[(3,4,5-triMethoxyphenyl)aMino]Methyl}quinazoline-2,4-diaMine
2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]- | [Molecular Formula]
C19H23N5O3 | [MDL Number]
MFCD00866404 | [MOL File]
52128-35-5.mol | [Molecular Weight]
369.42 |
| Chemical Properties | Back Directory | [Melting point ]
215-217 °C | [Boiling point ]
647.0±65.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO : ≥ 61.5 mg/mL (166.48 mM) | [form ]
Solid | [pka]
8.09±0.30(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Description]
Trimetrexate (TMQ) has been approved for the treatment of Pneumocystis carinii in patients with
AIDS and also exhibits antiprotozoal activity against Trypanosoma cruzi . The drug is available as a
single-ingredient medication, but it can be administered along with folinic acid in much the same
way that methotrexate is administered with calcium leucovorin in cancer chemotherapy.
Trimetrexate is a derivative of methotrexate. | [Uses]
Antineoplastic. | [Definition]
ChEBI: Trimetrexate is a member of quinazolines. It has a role as an antifungal drug. | [General Description]
The drug is available as a lyophilized powder in 5- or 30-mgvials for IV use. The drug is used to treat colorectal cancer,head and neck cancer as well as NSCLC. The mechanism ofaction of trimetrexate involves folate antagonism and inhibitionof thymidylate synthesis. Trimetrexate does not formintracellular polyglutamate adducts as does methotrexateand other related compounds. Resistance can occur by increasedexpression of the target enzyme, decreased bindingaffinity for the target enzyme, or decreased intracellulardrug transport. Trimetrexate is administered only by the IVroute and distributed throughout the body with extensivebinding to plasma proteins. The major catabolic pathwaysinvolve O-demethylation followed by glucuronide conjugation.The drug interaction and toxicity profiles are similar tothose for methotrexate. | [Mechanism of action]
Trimetrexate is considered to be a nonclassical folate antagonist, whereas methotrexate, the
structurally similar analogue of TMQ, is a classical folate antagonist. The difference between
these two drugs is that methotrexate, with its polar glutamate side chain, is transported into the
cell via a carrier-mediated transport system, whereas TMQ, without the glutamate moiety, is
absorbed by the cell via a passive diffusion. Once in the cell, TMQ inhibits DHFR. Trimetrexate
binds to Pneumocystis cari nii DHFR 1,500 times more strongly than trimethoprim and somewhat
more strongly than methotrexate. It also has been reported that TMQ readily enters the P. carinii
cell because of the lipophilic nature of this drug. Methotrexate and leucovorin are not able to
enter the cell, however, because the cell membrane of P. carinii does not possess the transporter
protein. | [Clinical Use]
Trimetrexate, when combined with the cytoprotective agent leucovorin, is more effective and better
tolerated than pentamidine in the treatment of PCP. Because the first- and second-line agents
are successful in only 50 to 75% of these cases, and because adverse reactions severely limit the
use of some of the older agents, TMQ may offer some advantages in treatment. Trimetrexate is
administered by IV infusion over 60 to 90 minutes and should be combined with the cytoprotective
drug leucovorin. The leucovorin protects against bone marrow suppression and against renal and
hepatic dysfunction. Leucovorin administration should continue for 72 hours after the last dose of
TMQ. Additionally, TMQ has been reported to be effective in the treatment of Chagas' disease. | [storage]
Store at -20°C |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
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