| Identification | Back Directory | [Name]
(Z)-5-(furan-2-ylmethylene)-2-thioxothiazolidin-4-one | [CAS]
521972-99-6 | [Synonyms]
Protonstatin-1
(Z)-5-(furan-2-ylmethylene)-2-thioxothiazolidin-4-one | [Molecular Formula]
C8H5NO2S2 | [MDL Number]
MFCD00228362 | [MOL File]
521972-99-6.mol | [Molecular Weight]
211.26 |
| Chemical Properties | Back Directory | [Melting point ]
230-231 °C(Solv: ethanol (64-17-5)) | [density ]
1.54±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.62±0.50(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Description]
Protonstatin-1 is a selective small-molecule inhibitor of PM H+ -ATPase activity that inhibits auxin transport. | [Uses]
Protonstatin-1 is a selective plasma membrane (PM) H+-ATPase inhibitor (IC50 of 3.9 μM) that inhibits auxin transport. Protonstatin-1 interacts with the PM H+-ATPase central loop and may thus impede the functions of the N- and/or P-domain to inhibit the pump activity[1][2]. | [References]
[1] Yongqing Yang, et al. Testing the polar auxin transport model with a selective plasma membrane H+ -ATPase inhibitor. J Integr Plant Biol. 2022 Jun;64(6):1229-1245. DOI:10.1111/jipb.13256
[2] Yongqing Yang, et al. Screening of protonstatin-1 (PS-1) analogs for improved inhibitors of plant plasma membrane H+-ATPase activity. Front Plant Sci. 2022 Oct 12:13:973471. DOI:10.3389/fpls.2022.973471 |
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