| Identification | Back Directory | [Name]
1-HEXADECYL LYSOPHOSPHATIDIC ACID | [CAS]
52603-03-9 | [Synonyms]
AGP 16:0
XLVRFPVHQPHXAA-LJQANCHMSA-N
ALKYL GLYCERO PHOSPHATE 16:0
1-HEXADECYL LYSOPHOSPHATIDIC ACID
1-HEXADECYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE
[(2R)-3-hexadecoxy-2-hydroxypropyl] dihydrogen phosphate
1,2-Propanediol, 3-(hexadecyloxy)-, 1-(dihydrogen phosphate), (2R)- | [Molecular Formula]
C19H41O6P | [MDL Number]
MFCD09951900 | [MOL File]
52603-03-9.mol | [Molecular Weight]
396.5 |
| Chemical Properties | Back Directory | [solubility ]
DMF: 5 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:1): 0.5 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group at the sn-1 position.1 LPA binds to five different G protein-coupled receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.2,3 | [Definition]
ChEBI: 1-hexadecyl-sn-glycerol 3-phosphate is a 1-alkyl-sn-glycerol 3-phosphate in which the 1-alkyl group is specified as hexadecyl. It is a conjugate acid of a 1-hexadecyl-sn-glycero-3-phosphate(2-). | [References]
1. Tsukahara, T., Tsukahara, R., Yasuda, S., et al. Different residues mediate recognition of 1-O-oleyl-lysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor γ J. Biol. Chem. 281(6),3398-3407(2006).
2. Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions Trends Cell Biol. 4(6),213-219(1994).
3. Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature Pharmacol. Rev. 54,265-269(2002). |
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