| Identification | Back Directory | [Name]
N,N'-bis(salicylideneamino)ethane-manganese(II) | [CAS]
53177-12-1 | [Synonyms]
EUK-8
EUK-8 >=95% (HPLC)
Manganese(salen) chloride
(Salen)manganese(III) chloride
(Salen)manganese(III) chloride (EUK-8)
N,N'-bis(salicylideneamino)ethane-manganese(II)
Chloro(bis(salicylidene)ethylenediamine)manganese
Chloro[N,N′-ethylenebis(salicylideneaminato)]manganese
N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis(nitrilomethylidyne)]bis[phenolato]](2-)-N,N′,O,O′]-manganese
(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese
N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II)
(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-alphaN)methylidyne]]bis[phenolato-alphaO]](2-)]manganese | [Molecular Formula]
C16H14ClMnN2O2 | [MOL File]
53177-12-1.mol | [Molecular Weight]
356.686 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble1mg/mL, clear | [form ]
powder | [color ]
faint to very dark brown | [Water Solubility ]
H2O: 1mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
[N,N 0-Disalicylidene-1,2-ethanediaminato-(2-)]manganese(III) Chloride is an oxidation catalysts and an enzyme mimetic. It also functions as an intermediate in the synthesis of manganese(III) complexes with fluorinated salen derivatives that exhibits antioxidant properties. | [Biochem/physiol Actions]
EUK-8 is a salen manganese complex that exhibit potent antioxidant activities. EUK-8 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-8 disrupts the pre-formed amyloid fibrils. EUK-8 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils. | [storage]
Store at -20°C |
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