| Identification | Back Directory | [Name]
ciclonicate | [CAS]
53449-58-4 | [Synonyms]
Bled
P-350
Rolil
Elastan
Vasargil
ciclonicate
Cortofludan
Cyclonicate
3-Pyridinecarboxylic acid, (1R,5S)-3,3,5-trimethylcyclohexyl ester, rel-
rel-3-Pyridinecarboxylic acid (1S*)-3,3,5β*-trimethylcyclohexane-1α*-yl ester | [EINECS(EC#)]
258-561-4 | [Molecular Formula]
C15H21NO2 | [MDL Number]
MFCD01692024 | [MOL File]
53449-58-4.mol | [Molecular Weight]
247.336 |
| Hazard Information | Back Directory | [Originator]
Bled, Poli, Italy ,1978 | [Definition]
ChEBI: Ciclonicate is an aromatic carboxylic acid and a member of pyridines. | [Manufacturing Process]
To a solution of 142 g (1 mol) of trans-3,3,5-trimethylcyclohexanol in 400 cc
of anhydrous benzene heated to 70 C is added gradually 178 g (1 mol) of
niacin chloride hydrochloride. Heating is carried out under reflux conditions for
3 hours, the solution is cooled, the ester hydrochloride is filtered off and then
recrystallized in an ethanol-ethyl ether mixture to obtain 227 g (80% yield) of
product melting at 155°C to 157°C.
By treating the hydrochloride with an aqueous solution of NaOH at 0°C, the
free base is obtained in the form of a viscous white liquid which boils at 115°C
under 0.05 mm. | [Therapeutic Function]
Vasodilator |
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