| Identification | Back Directory | [Name]
1，2-Dimethyl hydrazine | [CAS]
540-73-8 | [Synonyms]
SDMH
1，2-Dimethyl hydrazine
Hydrazine, 1,2-dimethyl-
Dimethyl hydrazine (symmetrical) | [Molecular Formula]
C2H8N2 | [MDL Number]
MFCD01741277 | [MOL File]
540-73-8.mol | [Molecular Weight]
60.0992 |
| Chemical Properties | Back Directory | [Appearance]
colourless or yellow hygroscopic liquid which fumes in air | [Melting point ]
-8.9°C | [Boiling point ]
87.05°C | [density ]
0.8274 | [refractive index ]
1.4209 | [pka]
9.29±0.70(Predicted) | [Stability:]
Stable. Incompatible with oxidizing agents, water, moisture. | [IARC]
2A (Vol. 4, Sup 7, 71) 1999 | [EPA Substance Registry System]
1,2-Dimethylhydrazine (540-73-8) |
| Hazard Information | Back Directory | [Chemical Properties]
1,2-Dimethylhydrazine is a colorless or yellow hygroscopic liquid and releases fumes in
air. 1,2-Dimethylhydrazine is stable and incompatible with oxidizing agents, water, and
moisture. Hydrazines include 1,1-dimethylhydrazine and 1,2-dimethylhydrazine, collectively.
Hydrazines in pure form are clear, colorless liquids that quickly evaporate in air.
Hydrazines smell somewhat like ammonia. Hydrazines are highly reactive and easily catch
fi re. 1,1-Dimethylhydrazine, and 1,2-dimethylhydrazine are somewhat similar in chemical
structure and reactivity. However, there are some clear differences in their production,
uses, and adverse health effects. There are many other hydrazine compounds. Hydrazines
are manufactured from chemicals such as ammonia, dimethylamine, hydrogen perox-
ide, and sodium hypochlorite. A small amount of hydrazine occurs naturally in some
plants. Large amounts of hydrazines are in different countries. 1,2-Dimethylhydrazine is a
research chemical and the quantities produced are likely to be much less.
Hydrazine has been used as a fuel source for rocket propellant and spacecraft, including
the space shuttle. Hydrazine is also used to treat boiler water to reduce corrosion and to
reduce other chemical substances. Hydrazine is used as a medicine and in the manufacture
of other medicines, farm chemicals, and plastic foams. 1,1-Dimethylhydrazine has been
used as a rocket propellant and in the manufacture of other chemical substances, while
the literature indicate that 1,2-dimethylhydrazine has no commercial use but is used in
researches to study colon cancer in experimental animals. | [Chemical Properties]
colourless or yellow hygroscopic liquid which fumes in air | [Definition]
ChEBI: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice. | [General Description]
A colorless liquid with an ammonia-like odor. Less dense than water. Flash point is 5°F. Contact irritate skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Used to make photographic chemicals. | [Air & Water Reactions]
Highly flammable. Fumes upon exposure to air . Soluble in water with evolution of heat. | [Reactivity Profile]
1，2-Dimethyl hydrazine dissolves, swells, and disintegrates many plastics [USCG, 1999]. | [Health Hazard]
Breathing of vapor causes pulmonary irritation, delayed gastro-intestinal irritation, tremors, and convulsions. Contact with skin or mucous membranes causes chemical burns. Can be absorbed through skin to cause systemic intoxication and convulsions. | [Health Hazard]
Inhalation exposure to hydrazines, cause adverse health effects and poisoning to animals
and humans. The symptoms of toxicity and poisoning include, but are not limited to,
injury to the lungs, liver, kidney, vomiting, uncontrolled shaking, lethargy (sluggishness),
coma, and neuritis (an infl ammation of the nerves), convulsions, tremors, seizures, and the
CNS. Effects on the nervous system have also been seen in animals exposed to hydrazine
and 1,1-dimethylhydrazine, but not to 1,2-dimethylhydrazine. | [Description]
1,2-Dimethylhydrazine is a flammable, colorless, fuming liquid with a fishy, amine-like odor.Molecular weight= 60.12; Boiling point = 8081℃;Freezing/Melting point = 29℃; Flash point = # 23℃.Hazard Identification (based on NFPA-704 M RatingSystem): Health 3, Flammability 3, Reactivity 2. Solublein water | [Uses]
1,2-Dimethylhydrazine (SDMH) unlike its analog 1,1-
dimethylhydrazine (UDMH) is used only in small quantities
as a research chemical. There are no known commercial uses,
although it was evaluated as a high-energy rocket fuel. The
material is a fuming, strongly alkaline, moderately volatile
liquid. | [Potential Exposure]
1,2-Dimethylhydrazine is an experimental rocket fuel and is used in chemical synthesis; a laboratory chemical. Mutagen | [First aid]
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting | [Carcinogenicity]
SDMH is carcinogenic to mice,
rats, and hamsters using a variety of exposure routes. Oral
doses of 21 mg/kg for 11 weeks produced intestinal tumors
in rats. A lower dose (3 mg/kg) in drinking water for
12 months produced liver hemangioendotheliomas.A
number of these tumors were metastatic. Mice given
doses of 60–90 mg/day in drinking water developed a variety
of tumors including angiosarcomas and lung adenomas
. Both oral administration and intraperitoneal
injection increased lung adenomas in the A/J strain
mouse. Hamsters also developed angiosarcomas,
intestinal tumors, and liver tumors following average daily
intakes of 160 mg in drinking water. An in-depth
description of the uniqueness of the colonic tumors was
presented. | [storage]
(1) Color Code—Red: Flammability Hazard: Storein a flammable liquid storage area or approved cabinetaway from ignition sources and corrosive and reactivematerials. (2) Color Code—Yellow Stripe (strong reducingagent): Reactivity Hazard; Store separately in an area isolated from flammables, combustibles, or other yellow-codedmaterials. (3) Color Code—Blue: Health Hazard/Poison(mutagen): Store in a secure poison location. Prior to working with SDMH you should be trained on its proper handling and storage. Store in tightly closed containers | [Shipping]
This compound requires a shipping label of“POISONOUS/TOXIC MATERIALS, FLAMMABLELIQUID.” It falls in Hazard Class 6.1 and Packing Group I. | [Incompatibilities]
Forms explosive mixture with air. Astrong reducing agent and strong base. Violent reactionwith strong oxidizers, strong acids, metallic oxides. Attackssome plastics, rubber, and coatings. May accumulate staticelectrical charges, and may cause ignition of its vapors. |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
45-23/24/25-51/53 | [Safety Statements ]
53-45-61 | [RIDADR ]
2382 | [HazardClass ]
6.1(a) | [PackingGroup ]
I | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Poison by ingestion, intraperitoneal,
intravenous, subcutaneous, and
intramuscular routes. Moderately toxic by
inhalation. Human mutation data reported.
A very dangerous fire hazard when exposedto heat, flame, or oxidizers. A hgh-energy
propellant for liquid-fueled rockets. When
heated to decomposition it emits toxic
fumes of NOx | [Hazardous Substances Data]
540-73-8(Hazardous Substances Data) |
|