| Identification | Back Directory | [Name]
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) | [CAS]
54135-60-3 | [Synonyms]
M50054
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
2,2-METHYLENEBIS-(1,3-CYCLOHEXANEDIONE)
2,2'-METHYLENE BIS CYCLOHEXANE-1,3-DIONE
1,3-Cyclohexanedione, 2,2'-methylenebis-
Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem
2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione | [EINECS(EC#)]
258-989-1 | [Molecular Formula]
C13H16O4 | [MDL Number]
MFCD00192291 | [MOL File]
54135-60-3.mol | [Molecular Weight]
236.26 |
| Hazard Information | Back Directory | [Uses]
A cell-permeable inhibitor of apoptosis induction. Inhibits caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml. | [Definition]
ChEBI: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione is a beta-diketone. | [Biological Activity]
m50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]in human fas-expressing wc8 cells, m50054 inhibited apoptosis by soluble human fas ligand in vitro cell death assay. m50054 inhibited the apoptotic u937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. m50054 inhibited apoptotic characters such as dna phosphatidylserine and fragmentation exposure in these cells. these anti-apoptotic effects were dependent on inhibition of caspase-3 activation. additionally, m50054 significantly inhibited anti-fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. alopecia (hair loss) symptoms were also significantly improved with topical treatment with m50054. m50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1] | [target]
Caspase | [References]
tsuda t, ohmori y, muramatsu h et al. inhibitory effect of m50054, a novel inhibitor of apoptosis, on anti-fas-antibody-induced hepatitis and chemotherapy-induced alopecia.eur j pharmacol. 2001 dec 14;433(1):37-45. |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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