| Identification | Back Directory | [Name]
adamexine | [CAS]
54785-02-3 | [Synonyms]
adamexine
N-[2-[[1-adamantyl(methyl)amino]methyl]-4,6-dibromophenyl]acetamide
N-[2-[[1-adamantyl(methyl)amino]methyl]-4,6-dibromo-phenyl]acetamide
N-[2-[[1-adamantyl(methyl)amino]methyl]-4,6-dibromo-phenyl]ethanamide | [EINECS(EC#)]
259-347-3 | [Molecular Formula]
C20H26Br2N2O | [MDL Number]
MFCD03106118 | [MOL File]
54785-02-3.mol | [Molecular Weight]
470.246 |
| Hazard Information | Back Directory | [Originator]
Adamexine ,ZYF Pharm Chemical | [Definition]
ChEBI: Adamexine is an aromatic amide. | [Manufacturing Process]
4.3 g 2-brommemtyl-4,6-dibromo-N,N-diacetylaniline and 1.65 g Nmethyladamantyl
amine in 100 ml of absolute ethanol were heated to reflux
for 8 hours. The ethanol was removed and a residue was washed with some
times with ether. The resulting hard mass was refluxed with 150 ml 2 N HCl
for 2 hours. The obtained product was cooled and stood for 10-12 hours at
4°C in a refrigerator. The crystalline 2-(N-(1-adamantyl)-Nmethylaminomethyl-
4',6'-dibromacetanilid hydrochloride (adamexine) was
filtered off and thoroughly washed with distilled water. It was recrystallized
from a mixture glacial acetic acid/water 2:1 (v/v) to give a white crystalline
powder, melting at 250°-254°C. The hydrochloride is better for a
pharmaceutical composition because of solubility in water. The free base may
be prepared by adding of an equivalent of any basic compound (NaOH,
NaHCO3 and so on). | [Therapeutic Function]
Mucolytic |
|
|