| Identification | Back Directory | [Name]
Pyridindolol | [CAS]
55812-46-9 | [Synonyms]
Pyridindolol
(R)-α-Hydroxymethyl-9H-pyrido[3,4-b]indole-1,3-dimethanol
1-[(1R)-1,2-Dihydroxyethyl]-9H-pyrido[3,4-b]indole-3-methanol
1-[3-(HYDROXYMETHYL)-9H-PYRIDO[3,4-B]INDOL-1-YL]ETHANE-1,2-DIOL
9H-Pyrido[3,4-b]indole-1,3-dimethanol, α1-(hydroxymethyl)-, (α1R)- | [Molecular Formula]
C14H14N2O3 | [MDL Number]
MFCD01939919 | [MOL File]
55812-46-9.mol | [Molecular Weight]
258.27 |
| Hazard Information | Back Directory | [Biological Activity]
Pyrindolol is a bacterial metabolite that has been found in S. alboverticillatus.1 It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg/ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated from C. perfringens, Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 μg/ml for all).1,2 | [References]
1.Aoyagi, T., Kumagai, M., Hazato, T., et al.Pyridindolol, a new β-galactosidase inhibitor produced by actinomycetesJ. Antibiot. (Tokyo)28(7)555-557(1975)
2.Kumagai, M., Aoyagi, T., and Umezawa, H.Inhibitory activity of pyridindolol on β-galactosidaseJ. Antibiot. (Tokyo)29(7)696-703(1976)
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