| Identification | Back Directory | [Name]
Midecamycin Acetate | [CAS]
55881-07-7 | [Synonyms]
Mom
Aids094885
Acecamycin
Miocamycin
Miokamycin
Aids-094885
Ponsinomycin
Acythylmedecamycin
Midecamycin Acetate
Midecamycin (Medemcyin)
3'',9-Diacetylmydecamycin
9,3''-Di-O-acetylmidecamycin
Midecamycin Acetate USP/EP/BP
Leucomycin V, 3B,9-diacetate 3,4B-dipropanoate
Leucomycin V, 3B,9-diacetate 3,4B-dipropanoate (9CI)
(1S,13S,7R,11R,14R,16R)-13-[5-(4-Acetyloxy-4,6-dimethyl-5-propoxyperhydropyran-2-yloxy)-4-(dimethylamino)-3-hydroxy-6-methylperhydropyran-2-yloxy]-12-methoxy-7,16-dimethyl-8-oxa-9-oxo-14-(2-oxoethyl)-11-propoxycyclohexadeca-2,4-dieny, acetate | [EINECS(EC#)]
259-879-6 | [Molecular Formula]
C45H71NO17 | [MDL Number]
MFCD00869591 | [MOL File]
55881-07-7.mol | [Molecular Weight]
898.046 |
| Chemical Properties | Back Directory | [Melting point ]
~220° (with coloration) | [alpha ]
D25 -53° (c = 1.0 in chloroform); D20 -74° (c = 1 in methanol) | [Boiling point ]
878.7±65.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [pka]
13.06±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Miokamycin (midecamycin acetate) is
a macrolide antibiotic useful in the
treatment of respiratory tract,
dermatological and surgical infections
due to grampositive bacteria and
mycoplasmas. | [Originator]
Meiji Seika (Japan) | [Brand name]
MIOCAMYCIN | [Pharmaceutical Applications]
A semisynthetic diacetyl derivative of midecamycin A1. It is generally less active than erythromycin and some strains of H. influenzae and E. faecalis are resistant. It is rapidly and extensively metabolized, though some metabolites retain antibacterial activity.
Absorption of the dry formulation is unaffected by food, whereas that of the oral suspension is delayed. In various studies the peak plasma concentration was 1.65, 1.31–3 and 1.3–2.7 mg/L after doses of 400, 600 and 800 mg, respectively.
It is said to exhibit less toxicity than earlier macrolides. Attention has been paid to its interaction with theophylline, which resembles that of other macrolides. It is of limited availability. |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
http://www.weikeqi-biotech.com/ |
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