| Identification | Back Directory | [Name]
3-oxododecanal | [CAS]
56505-80-7 | [Synonyms]
3-oxododecanal
Dodecanal, 3-oxo-
3-Oxododecanal (Decanoyl acetaldehyde) | [Molecular Formula]
C12H22O2 | [MDL Number]
MFCD01729598 | [MOL File]
56505-80-7.mol | [Molecular Weight]
198.3 |
| Hazard Information | Back Directory | [Description]
Houttuynin is one of the main ingredients in the volatile oil derived from jicai 蕺菜 (Houttuynia cordata Thunb), which belongs to the family Saururaceae, and is also
named as yuxingcao 鱼腥草 because of its fishlike smells when grated. H. cordata
has been widely used in traditional Chinese medicines and is recorded in Grand
Compendium of Materia Medica. H. cordata is used in the treatment of skin diseases, hemorrhoids, and certain diseases of women, relieving fever, resolving toxicity, reducing swelling, draining pus, and promoting urination. H. cordata is available
in China and India. | [Physical properties]
Appearance: aromatic oil with a volatile odor, yellow oily liquid. Solubility: soluble
in methanol, ethanol, ether, and petroleum ether; insoluble in water; easily
polymerizable | [History]
In 1952, houttuynin was firstly found in the volatile oil extracted from Houttuynia by
steam distillation. The chemical structure was named decanoyl acetaldehyde.
However, houttuynin is easy to polymerize and became invalid. In 1971, Chinese
scholars synthesized sodium houttuyfonate (houttuyninum, HOU), which is an addition compound of sodium bisulfite and houttuynin. HOU is more stable and maintains
the original antibacterial activity. HOU possessed broad-spectrum antibacterial
and anti-inflammatory activities, diuretic swelling, rapid antifebrile, antivirus and
antitumor proliferation, increased immunity, and other pharmacological effects.Neo-houttuyninum as the other derivative of houttuynin possesses more obvious
inhibitory effect on a variety of bacteria and is used for the treatment of infectious
diseases.Since houttuynin was found 60? years ago, Houttuynia injection preparations
have been developed, such as Houttuynia injection, neo-houttuyfonate sodium chloride injection, neo-houttuyfonate injection, etc. These drugs are commonly used in
clinical antimicrobial drugs. However, these injection preparations were withdrawed for serious adverse reactions in 2006, and continued to be used in clinic
since 2008. | [Definition]
ChEBI: Decanoyl acetaldehyde is a fatty aldehyde. | [Indications]
Houttuynin is recorded in the Pharmacopoeia of the People’s Republic of China
(1995).Houttuynin preparations include Houttuynia injection, sodium neo-houttuyfonate
injection, sodium neo-houttuyfonate and sodium chloride injection, sodium houttuyfonate tablets, and tabellae natrii houttuyfonatis. These preparations are mainly
used to treat chronic bronchitis, pediatric pneumonia, and other respiratory inflammatory diseases; cervicitis, annex inflammation, pelvic inflammatory disease,
chronic cervicitis, and other gynecological inflammation; and also other skin diseases such as psoriasis. Houttuynin preparations also include sodium houttuyfonate
suppository and compound Houttuynia tablets. The former is used to treat cervical
erosion, and the latter is used to treat acute pharyngitis and acute tonsillitis. | [Pharmacology]
Houttuynin is reported as a major antibacterial constituent in the volatile oil of H.
cordata. Houttuynin exhibits significant inhibitory effects on Staphylococcus
aureus, pneumococcus, and other bacteria as well as certain fungi and also has certain antiviral and anti-inflammatory effects. It is reported that houttuynin could
reduce cardiomyocyte cross-section area and collagen deposition. Houttuynin attenuates ventricular remodeling in coronary artery ligation rats by restricting the excessive activation of rennin-angiotensin-aldosterone system (RAAS) and peroxidation
. Houttuynin also shows hypolipidemic and anti-atherosclerotic effects.Houttuyninum has a significant inhibitory effect on Candida albicans,
Cryptococcus neoformans, and Brochothrix thermosphacta. Houttuyninum has
anti-inflammatory and analgesic effects, and the inhibition of inflammation is
related to NF-κB and MCP-1. In recent years, studies have shown that intragastric administration of houttuyninum can increase apoptosis of the rheumatoid arthritis synovial cell and reduce joint index and inflammation factor levels in rheumatoid
arthritis rat model | [Clinical Use]
Houttuynin and its derivatives are used to treat milk moths, lung carbuncle, leaching
disease, carbuncle swollen sore, and other infectious diseases. Currently it is used
mainly for the treatment of gynecological diseases and respiratory system, especially upper respiratory tract infection. However, there are side effects associated
with the use of these injection preparations, mainly involving the cardiovascular
system, gastrointestinal system, blood system, and skin or kidney. |
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