Identification | Back Directory | [Name]
2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE | [CAS]
568544-03-6 | [Synonyms]
GSTO1-IN-1 GSTO1 inhibitor 1 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]- | [Molecular Formula]
C10H12Cl2N2O3S | [MDL Number]
MFCD03965279 | [MOL File]
568544-03-6.mol | [Molecular Weight]
311.18 |
Hazard Information | Back Directory | [Biological Activity]
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 31 nM. | [in vitro]
GSTO1-IN-1 (C1-27) potently inhibits GSTO1 enzyme activity with an IC 50 value of 31 nM. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations. | [target]
|
|
Company Name: |
Twochem Co.Ltd.
|
Tel: |
021-58111628 15800915896 |
Website: |
cn.twochem.com |
Company Name: |
InvivoChem
|
Tel: |
13549236410 |
Website: |
https://www.invivochem.cn/ |
|