| Identification | Back Directory | [Name]
SPLITOMICIN | [CAS]
5690-03-9 | [Synonyms]
Spitomicin
Splitomycin
SPLITOMICIN
Splitomicin >
1H-Benzo[f]chromen-3(2H)-one
1,2-Dihydro-3H-benzo[f]chromen-3-one
1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE
2-Hydroxy-1-naphthalenepropanoic acid delta-lactone | [Molecular Formula]
C13H10O2 | [MDL Number]
MFCD03792600 | [MOL File]
5690-03-9.mol | [Molecular Weight]
198.217 |
| Chemical Properties | Back Directory | [Melting point ]
73-74.5℃ | [storage temp. ]
2-8°C
| [solubility ]
insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic; ≥9.05 mg/mL in DMSO | [form ]
solid
| [color ]
White to Almost white |
| Hazard Information | Back Directory | [Uses]
Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50=60μM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. | [Definition]
ChEBI: A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 69, p. 2341, 1947 DOI: 10.1021/ja01202a027 | [General Description]
A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 μM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket. | [Biological Activity]
Inhibitor of Sir2p (IC 50 = 60 μ M), an NAD + -dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast. | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
+4°C |
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