| Identification | Back Directory | [Name]
BUDIPINE | [CAS]
57982-78-2 | [Synonyms]
budipin
BUDIPINE
BUDIPINE USP/EP/BP
BUDIPINE(FORR&DONLY)
4,4-diphenyl-1-tert-butyl-piperidine
1-TERT-BUTYL-4,4-DIPHENYL-PIPERIDINE
1-(1,1-dimethylethyl)-4,4-diphenyl-piperidin
1-(1,1-dimethylethyl)-4,4-diphenylpiperidine
Piperidine,1-(1,1-dimethylethyl)-4,4-diphenyl- | [EINECS(EC#)]
261-062-4 | [Molecular Formula]
C21H27N | [MDL Number]
MFCD00866585 | [MOL File]
57982-78-2.mol | [Molecular Weight]
293.45 |
| Chemical Properties | Back Directory | [Melting point ]
108.5°C | [Boiling point ]
425.29°C (rough estimate) | [density ]
0.9665 (rough estimate) | [refractive index ]
1.4900 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : 25 mg/mL (85.19 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.36±0.10(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Description]
Parkinsan was launched in Germany as a centrally-active anti-Parkinsonian
agent. It can be prepared in three steps: a Mannich-aldol sequence to assemble the
4-phenylpiperidine scaffold followed by a Friedel-Crafts reaction to introduce the
second phenyl ring. Parkinsan is effective for the treatment of Parkinsonian tremors
and is similar in action to, but more potent than, biperiden. It exhibits use-dependent,
open channel, uncompetitive NMDA receptor antagonistic activity. This may occur by
binding to the PCP site in addition to interacting with sigma, binding sites in the frontal
cortex. Parkinsan is also an antagonist at presynaptic muscarinic autoreceptors but
facilitation of direct or indirect dopaminergic transmission does not contribute to its
actions. While its mechanism of action is not completely understood, it has a weak
inhibitory effect on dopamine reuptake, inhibits evoked GABA release (with low affinity
for GABA-A receptors and a lower affinity for benzodiazepine receptors), and has a
weak inhibitory effect on MAO-B. | [Originator]
Byk Gulden (Germany) | [Definition]
ChEBI: Budipine is a diarylmethane. | [Manufacturing Process]
24.4 g of 1-(t-butyl)-4-hydroxy-4-phenylpiperidine are suspended in 150 ml of
anhydrous benzene. 61.5 g of finely pulverized anhydrous aluminum chloride
are added in portions thereto within 25 min while stirring. The reaction
temperature increases on starting addition of aluminum chloride to about
45°C. After about 20 min the temperature is increased to and maintained at
about 50° to 55°C for about 1 hour. The resulting reaction solution is cooled
to about 20°C and is poured into a mixture of ice and concentrated
hydrochloric acid. After warming the mixture to room temperature, the
hydrochloric acid layer together with the dark oil formed on decomposition is
separated from the benzene layer and is washed with benzene. Water is
added to said hydrochloric acid -oil phase, while stirring, in portions and in an
amount sufficient to produce an almost clear solution. Said acid solution is
rendered alkaline by the addition of 40% sodium hydroxide solution whereby the mixture is well cooled. The alkalized mixture is repeatedly extracted with
ether. The combined ether extracts are dried over anhydrous potassium
carbonate and are concentrated by evaporation of the ether. 24 g of the crude
base are obtained as residue in the form of yellowish oil. A water clear oil
boiling at 129-131°C/0.005 mm Hg is recovered by distillation of said crude
oil in a high vacuum. The oil solidifies to crystals on standing for a short
period of time. After recrystallization from aqueous dimethylformamide, the
resulting 1-methyl-4,4-diphenylpiperidine has a melting point of 72-74°C.
Its hydrochloride is produced by dissolving the base in acetic acid ethyl ester
and adding an ethereal hydrochloric acid solution thereto. After
recrystallization from acetic acid ethyl ester, the melting point of the
hydrochloride is 152-154°C. | [Brand name]
Parkinsan | [Therapeutic Function]
Antiparkinsonian, Antidepressant | [storage]
Store at -20°C |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
3A Chemicals
|
| Tel: |
400-668-9898 |
| Website: |
www.3achem.com |
|