Identification | Back Directory | [Name]
SMI-16a | [CAS]
587852-28-6 | [Synonyms]
SMI-16a SMI-16A;SMI 16A;SMI16A PIM1/2 Kinase Inhibitor VI SMI-16a(PIM1/2 Kinase Inhibitor VI) 2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]- | [Molecular Formula]
C13H13NO3S | [MOL File]
587852-28-6.mol | [Molecular Weight]
263.31 |
Hazard Information | Back Directory | [Description]
SMI-16a is a Pim-1 kinase inhibitor (IC50 = 63 nM).1 It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 μM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G1 phase in DU145 cells. |
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Company Name: |
Twochem Co.Ltd.
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Tel: |
021-58111628 15800915896 |
Website: |
http://cn.twochem.com |
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