| Identification | Back Directory | [Name]
Methyl tetrazine OH | [CAS]
58884-35-8 | [Synonyms]
Methyl tetrazine OH
Me-tetrazine-phenol
4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol | [Molecular Formula]
C9H8N4O | [MDL Number]
MFCD24716961 | [MOL File]
58884-35-8.mol | [Molecular Weight]
188.19 |
| Chemical Properties | Back Directory | [Melting point ]
224-226 °C | [Boiling point ]
434.9±47.0 °C(Predicted) | [density ]
1.322±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.17±0.15(Predicted) | [color ]
Pink to red |
| Hazard Information | Back Directory | [Description]
4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenol is a linker containing a methyltetrazine and a hydroxy moiety. This reagent enables simple and efficient incorporation of a tetrazine moiety onto antibodies, TCO-containing peptides and other TCO-attached molecules. | [Uses]
4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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