ChemicalBook--->CAS DataBase List--->592542-59-1

592542-59-1

592542-59-1 Structure

592542-59-1 Structure
IdentificationBack Directory
[Name]

(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT
[CAS]

592542-59-1
[Synonyms]

CS-1407
Rigosertib
Rigosertib(acid)
rigosertib(PI3K/Plk1 inhibitor)ORPHAN DRUG
3: PN: WO2006074149 PAGE: 45 claiMed sequence
(E)-2-((2-Methoxy-5-(((2,4,6-triMethoxystyryl)sulfonyl)Methyl)phenyl)aMino)acetic acid
N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine
Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phenyl]-
(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT
[Molecular Formula]

C21H25NO8S
[MDL Number]

MFCD11655911
[MOL File]

592542-59-1.mol
[Molecular Weight]

451.49
Chemical PropertiesBack Directory
[Melting point ]

172-174 °C(Solv: acetone (67-64-1))
[Boiling point ]

756.1±60.0 °C(Predicted)
[density ]

1.332±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C,unstable in solution, ready to use.
[solubility ]

Soluble in DMSO
[form ]

Powder
[pka]

4.23±0.20(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

Rigosertib is a microtubule destabilizing agent which may be employed in the treatment of high-?risk myelodysplastic syndrome.
[Definition]

ChEBI: Rigosertib is an N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine in which the double bond has E-configuration. It is a non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM and exhibits anti-cancer properties. It has a role as a microtubule-destabilising agent, an EC 2.7.11.21 (polo kinase) inhibitor, an apoptosis inducer and an antineoplastic agent. It is a conjugate acid of a rigosertib(1-).
[Biological Activity]

rigosertib is a dual inhibitor of phosphoinositide 3-kinase (pi3k) and polo-like kinase 1 (plk1) [1].
[in vitro]

studies show that rigosertib inhibits the pi3k/akt pathway, down-regulates cyclin d1, induces noxa and bim and activates the jnk pathway in human leukemic cells. rigosertib induces apoptosis of a variety of human tumor cell lines including breast, prostate, ovarian, pancreatic, sclc, colorectal, melanoma and et al. for instant, it shows anti-tumor efficacy in bt20, mcf-7, bt474, ov-car-3, a549 and hct-116 with ic50 values of 80nm, 75nm, 50nm, 75nm, 90nm and 75nm, respectively. in addition, rigosertib is also effective against the drug resistant tumor cell lines. it potently inhibits tumor growth with ic50 values of 100nm and 50nm against mes-sa/dx5 and cem/c2, respectively. moreover, it is reported that rigosertib can affect the cell cycle of both normal cells and tumor cells. rigosertib leads to a blockade of cell cycle progression in the g1 and g2/m phases in normal diploid human fetal lung cells. when treated with du145 cells, rigosertib induces cell cycle arrest in g2/m phase [2].
[References]

[1] anderson r t, keysar s b, bowles d w, et al. the dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. molecular cancer therapeutics, 2013, 12(10): 1994-2005.
[2] reddy m v r, venkatapuram p, mallireddigari m r, et al. discovery of a clinical stage multi-kinase inhibitor sodium (e)-2-{2-methoxy-5-[(2′, 4′, 6′-trimethoxystyrylsulfonyl) methyl] phenylamino} acetate (on 01910. na): synthesis, structure–activity relationship, and biological activity. journal of medicinal chemistry, 2011, 54(18): 6254-6276.
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