| Identification | Back Directory | [Name]
3,6,9,12-tetraoxatetradecane-1,14-diyl diacrylate | [CAS]
59256-52-9 | [Synonyms]
Einecs 261-677-8
Bis-acrylate-PEG5
3,6,9,12-tetraoxatetradecane-1,14-diyl diacrylate
Bispropenoic acid 3,6,9,12-tetraoxatetradecane-1,14-diyl ester
2-Propenoic acid,3,6,9,12-tetraoxatetradecane-1,14-diyl ester (9CI)
2-Propenoic acid, 1,1'-(3,6,9,12-tetraoxatetradecane-1,14-diyl) ester | [EINECS(EC#)]
261-677-8 | [Molecular Formula]
C16H26O8 | [MDL Number]
MFCD32706469 | [MOL File]
59256-52-9.mol | [Molecular Weight]
346.37 |
| Hazard Information | Back Directory | [Biological Activity]
Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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