ChemicalBook--->CAS DataBase List--->5949-11-1

5949-11-1

5949-11-1 Structure

5949-11-1 Structure
IdentificationBack Directory
[Name]

CINCHONINE HYDROCHLORIDE
[CAS]

5949-11-1
[Synonyms]

Nsc215195
Cinchonine monohydro
CINCHONINE HYDROCHLORIDE
cinchonine,monohydrochloride
CINCHODININE DIHYDROCHLORIDE
Cinchonine Hydrochloride Hydrate
CINCHONINE HYDROCHLORIDE USP/EP/BP
CINCHONINE HYDROCHLORIDE N-HYDRATE
Cinchonan-9(S)-ol monohydrochloride
monohydrochloride,(9s)-cinchonan-9-o
(+)-CINCHONINE HYDROCHLORIDE N-HYDRATE
Cinchonine hydrochloride, reagent grade
(S)-Quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride
[EINECS(EC#)]

621-239-2
[Molecular Formula]

C19H23ClN2O
[MDL Number]

MFCD00079070
[MOL File]

5949-11-1.mol
[Molecular Weight]

330.85
Chemical PropertiesBack Directory
[Melting point ]

208-218 °C(lit.)
[storage temp. ]

under inert gas (nitrogen or Argon) at 2-8°C
[CAS DataBase Reference]

5949-11-1
Safety DataBack Directory
[Hazard Codes ]

Xn,Xi
[Risk Statements ]

20/21/22-36/37/38
[Safety Statements ]

36/37-36-26
[RIDADR ]

1544
[WGK Germany ]

3
[RTECS ]

GD2962020
[F ]

8
[HazardClass ]

6.1(b)
[PackingGroup ]

III
Hazard InformationBack Directory
[Description]

Cinchonine hydrochloride not only possesses the required solubility and bioavailability criteria for pharmaceutical formulations while retaining desired therapeutic properties, but is also very stable in solution, which facilitates the preparation of aqueous formulations, especially injections.
[Uses]

Cinchonine hydrochloride can be used as an inhibitory substance for the phenomenon of "multidrug resistance" (MDR). In particular, cinchonine hydrochloride compositions are useful in the treatment of cancer-related diseases with MDR phenomena.
[Biological Activity]

Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural compound in cinchona bark with antimalarial activity. It can activate endoplasmic reticulum stress to induce apoptosis in human hepatoma cells.
[storage]

Store at -20°C
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